Hat jemand Erfahrungen mit Nikotinpflaster-Test von Dr. Leitzke?

@albert Bei Small fiber Neuropathie ist das nicht der Fall, das würde dann die großen Nervenfasern betreffen und wäre einfacher messbar. 

@albert da wären aber die großen Nervenfasern betroffen und das würde man dann schon an der Nervenleitgeschwindigkeit sehen. Chronisch inflammstorisch demylisierende Polyneuropathie (CIDP). Die chronische Form des Guillaine - Barree- Syndroms.

Bei der SFN sind doe großen Nevenfasern ja nicht betroffen folglich ist die NLG auch nicht verändert.. Auch die  Prognose wäre bei weitem noch negativer als bei der SFN.

Ach, hatte gedacht meine Antwort wäre nicht gepostet worden irgendwie, naja jetzt hast du eine noch ausführlichere Antwort 😉 

Ich glaube, dass @clarissa das Problem mal angesprochen hat.

Habe noch etwas im englischsprachigen FAQ gefunden, was vielleicht interessant sein könnte:

"30. Small Fiber Neuropathy. “For a few days now, I have had more burning pain again. Does anyone know an explanation for this? Since I have such a good feeling with the NP, I don’t want to stop.”

This could be:
1. A kind of Herx/Verx which would make it feel worse, but be a good sign.
2. Or it might be due to reduced peripheral blood flow from the nicotine which might make it feel worse while on the patch.
3. It also might be the increased receptor expression that comes with nicotine over time. That increased expression might be painful until the body finds a new homeostasis.
4. Or something else... These are all just guesses based on the previous science on nicotine. We are all pioneers here.

Consider taking things like ALA, which is good for nerve repair. And ask your doctor about any anticoags like aspirin or Natto which would help with circulation…

Another therapy that might help is contrast therapy. The switching between warm and cold water acts like a pump to get more blood flowing in the peripheral tissues. Like exercise for the tiny peripheral vascular muscles."

Quelle: https://docs.google.com/document/d/1j6q7i0fYlMSCen87zaerh54SGc-jSM8TE6MbcKOl7dk/edit?tab=t.0

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37. Nicotine helps, but then it is causing (or bringing) back the SFN (small fiber neuropathy) pain which had been getting better. What should I do?
    
    In short. I don't know what to say. Nicotine and SFN might be a bad mix!

SFN (small fiber neuropathy) is common in many people with LC or ME and there is no clear science about nicotine and its effects on SFN. Some pain is seen as a sign of healing/Herx/Verx, but if nicotine is making it worse, then pushing through the pain would be dangerous.

Maybe you should only use a low dose for 2 or 3 days at a time to see if you can get benefits without the downsides.

I don't suggest pushing through unless your doctor who treats the SFN says it is OK to do so. Unfortunately, We are all just guinea pigs testing on ourselves.

In this observational study, low vitamin D and smoking were associated with SFN

https://www.frontiersin.org/articles/10.3389/fmed.2022.1051967/full

This study is observational and Smoking is very different from nicotine...

Maybe the nicotine is increasing the signaling which also increases the negative signals. This can also be dose-dependent since higher doses increase desensitization. In this case, the problem might be the desensitization of neurons which might not happen if lower doses or shorter rounds are tried.

From animal studies, nicotine should reduce pain levels, but that can come at the cost of slower nerve regeneration (if you have damaged nerves).

Just speculation. I wish I could help more! Any suggestions on research that would shed light on this are welcome."

Quelle: S.o.